The Comet Assay in Toxicology (Issues in Toxicology); 2009

Editors: Alok Dhawan, Diana Anderson

Book Series: Issues in Toxicology

The Comet Assay in Toxicology is the first book of its kind to be devoted exclusively to the Comet assay and its applications as an important tool in modern toxicology. This multi-author book will serve as both a reference and a guide to investigations in the biomedical, biochemical and pharmaceutical sciences. Written by investigators from the fields of genetic toxicology and human epidemiology, the authors have first-hand knowledge from their chosen sub-specialities and are active contributors to the peer-reviewed scientific literature.   

Bile Acids: Toxicology and Bioactivity (Issues in Toxicology); 2008

Editors: Gareth J. Jenkins, Laura Hardie

Book Series: Issues in Toxicology

 

This book is the first book to comprehensively cover the important properties of Bile acids and Bile acid Toxicology. Bile acids are increasingly being seen as important carcinogenic agents in cancers and there is wide recognition of their role in obesity linked diseases. Topics covered in this book include synthesis and chemistry, regulation and biotransformation in vivo, Bile acid induced cell death, genotoxicity, Bile acid induced gene expression and cell signaling abnormalities, and liver disease, colorectal cancer, esophageal cancer, and obesity.

Cytochrome P450: Role in the Metabolism and Toxicity of Drugs and other Xenobiotics (Issues in Toxicology); 2008

Editor: Costas Ioannides

Book Series: Issues in Toxicology

The enzyme system, cytochromes P450, comprises a number of families/subfamilies, and the focus of the book is to deal with each individually, furnishing information directly relevant to scientists involved in the development of chemicals, in particular in the evaluation of their safety. The book deals extensively with each family/subfamily of the cytochromes P450 that contribute to the metabolism of xenobiotics. The book has contributions from internationally respected scientists who are research-active in the relevant areas. The authors have made extensive use of figures and tables so that the reader can access the necessary information without always having to read the text. In addition, a very extensive, user-friendly index is a unique hallmark of the book.

Male-mediated Developmental Toxicity (Issues in Toxicology); 2007

Editors: Diana Anderson, Martin H. Brinkworth

Book Series: Issues in Toxicology

The issue of male germ line mutagenesis and the effects on developmental defects in the next generation has become increasingly high profile over recent years. Mutations are thought to be becoming more prevalent as a result of: exposure to chemicals in the environment; anti-cancer regimes that use genotoxic agents and assisted conception techniques. In addition to the increasing frequency of mutations in the general population, attention is also being given to the effects of epigenetic events on future generations. Male-mediated Developmental Toxicity discusses these issues comprehensively and includes further analysis on the fundamental mechanisms of mutations. With both clinical and experimental sections, written by leading experts in the field, this book will appeal to both medical practitioners and researchers. 

Hair in Toxicology: An Important Bio-monitor (Issues in Toxicology); 2005

Editor: Desmond John Tobin

Book Series: Issues in Toxicology

Hair in Toxicology: An Important Biomonitor is the first book of its kind devoted exclusively to in-depth analysis of the hair shaft as an important tool for a diverse range of scientific investigations. This authoritative book combines contributions from experts in academic, governmental and industrial environments, to provide a unique, comprehensive look at hair as a biomonitor in toxicology.